Bourhis J, Wibault P, Lusinchi A, Bobin S, Luboinski B, Eschwege F
Institut Gustave Roussy, Villejuif, France.
Curr Opin Oncol. 1997 May;9(3):262-6. doi: 10.1097/00001622-199709030-00008.
Considerable interest has been shown in recent years about hyperfractionated and accelerated radiation therapy for head and neck squamous cell carcinomas. The first randomized trial showing an advantage for hyperfractionation in terms of tumor control was the European Organization for Research and Treatment of Cancer 22791 trial. More recently, accelerated radiotherapy has been tested in many studies showing that high total doses of radiation could be delivered in overall treatment time shorter than conventional radiation therapy. The benefit of accelerated radiation therapy has been reported in some recently completed randomized trials, which suggests that rapid repopulation of surviving tumor cells during radiation therapy is a major determinant to obtain cure in this type of cancer.
近年来，头颈部鳞状细胞癌的超分割和加速放射治疗引起了广泛关注。第一项显示超分割在肿瘤控制方面具有优势的随机试验是欧洲癌症研究与治疗组织22791试验。最近，许多研究对加速放射治疗进行了测试，结果表明在总治疗时间短于传统放射治疗的情况下，可以给予高总剂量的辐射。一些最近完成的随机试验报告了加速放射治疗的益处，这表明在放射治疗期间存活肿瘤细胞的快速再增殖是治愈这类癌症的主要决定因素。
