Pérez A, Caixàs A, Carreras G, Mauricio D, Pou J M, Serrat J, Gómez-Gerique J, de Leiva A
Department of Endocrinology and Nutrition, Hospital de la Santa Creu l Sant Pau, Autonomous University of Barcelona, Spain.
Diabetes Res Clin Pract. 1997 May;36(2):83-90. doi: 10.1016/s0168-8227(97)00033-8.
Major lipoprotein mass and composition were assessed in 45 subjects with insulin dependent diabetes mellitus (IDDM), before and after 2 months of intensive insulin therapy (IIT) and in 40 healthy control subjects. As compared to the control group, diabetic subjects at baseline had higher low density lipoprotein (LDL) and lower high density lipoprotein (HDL) masses. Expressing each lipoprotein constituent as a percent of total lipoprotein mass, very low density lipoprotein (VLDL) of diabetic patients was enriched in cholesterol and phospholipid and depleted in triglyceride and protein; IDL had higher triglyceride and phospholipid and lower cholesterol and protein proportion; LDL was depleted in protein and enriched in triglyceride; HDL was depleted in protein and enriched in triglyceride, cholesterol and phospholipid. After 2 months of IIT, HbA1c fell from 10.3 +/- 2 to 7.5 +/- 2% (P < 0.0001) and so did VLDL mass, which was lower than in control subjects. In addition, LDL and HDL masses, as well as triglyceride and cholesterol proportion in IDL particles normalized. The other compositional abnormalities improved without complete normalization. Thus, intensive insulin therapy in IDDM subjects brought quantitative lipoprotein alterations to normal even subnormal range, while most of the composition abnormalities improved without reaching complete normalization.
对45名胰岛素依赖型糖尿病（IDDM）患者在强化胰岛素治疗（IIT）2个月前后以及40名健康对照者进行了主要脂蛋白质量和组成的评估。与对照组相比，糖尿病患者基线时的低密度脂蛋白（LDL）质量较高，高密度脂蛋白（HDL）质量较低。将每种脂蛋白成分表示为总脂蛋白质量的百分比，糖尿病患者的极低密度脂蛋白（VLDL）富含胆固醇和磷脂，甘油三酯和蛋白质含量降低；中间密度脂蛋白（IDL）的甘油三酯和磷脂含量较高，胆固醇和蛋白质比例较低；LDL的蛋白质含量降低，甘油三酯含量增加；HDL的蛋白质含量降低，甘油三酯、胆固醇和磷脂含量增加。IIT 2个月后，糖化血红蛋白（HbA1c）从10.3±2降至7.5±2%（P<0.0001），VLDL质量也下降，低于对照组。此外，IDL颗粒中的LDL和HDL质量以及甘油三酯和胆固醇比例恢复正常。其他组成异常有所改善，但未完全恢复正常。因此，IDDM患者的强化胰岛素治疗使脂蛋白定量改变恢复到正常甚至低于正常范围，而大多数组成异常虽有所改善但未完全恢复正常。
