Huang Z, Himes J H
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA.
Epidemiology. 1997 Mar;8(2):192-5. doi: 10.1097/00001648-199703000-00012.
We examined prospectively the associations of bone density and bone dimensions with risk of hip fracture using data from the first National Health and Nutrition Examination Survey and its three follow-up studies. A cohort of 1,489 white women age 45 years or older who received detailed medical examinations in the baseline survey in 1971-1975 were subsequently contacted in 1982-1984, 1986, and 1987. Bone density and hand bone dimensions at several sites were measured at baseline. Fifty incident hip fractures were identified during the follow-up studies. Using Cox regression analyses, we found a relative risk of 11 for women with bone density below the 5th percentile, compared with those above the 75th percentile (95% confidence interval = 2.2-58). Women with smaller external bone dimensions also faced increased risk of hip fracture (relative risk = 4.6 for dimensions below the 5th percentile vs above the 75th percentile; 95% confidence interval = 1.5-14). On the other hand, internal bone dimensions were not associated materially with hip fracture.
我们利用第一次全国健康与营养检查调查及其三项随访研究的数据，前瞻性地研究了骨密度和骨尺寸与髋部骨折风险之间的关联。1971年至1975年基线调查中接受详细医学检查的1489名45岁及以上白人女性队列，随后在1982年至1984年、1986年和1987年接受随访。在基线时测量了几个部位的骨密度和手部骨尺寸。在随访研究中确定了50例髋部骨折病例。通过Cox回归分析，我们发现骨密度低于第5百分位数的女性与高于第75百分位数的女性相比，相对风险为11（95%置信区间=2.2-58）。外部骨尺寸较小的女性髋部骨折风险也增加（尺寸低于第5百分位数与高于第75百分位数相比，相对风险=4.6；95%置信区间=1.5-14）。另一方面，内部骨尺寸与髋部骨折没有实质性关联。
