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用针对γ干扰素而非肿瘤坏死因子的特异性抗体中和牛伴刀豆球蛋白A T细胞上清液介导的抗反刍兽无形体活性。

Neutralization of bovine concanavalin-A T cell supernatant-mediated anti-Cowdria ruminantium activity with antibodies specific to interferon gamma but not to tumor necrosis factor.

作者信息

Mahan S M, Sileghem M, Smith G E, Byrom B

机构信息

UF/USAID/SADC Heartwater Research Project, Causeway, Zimbabwe.

出版信息

Parasite Immunol. 1996 Jun;18(6):317-24. doi: 10.1046/j.1365-3024.1996.d01-106.x.

Abstract

In an earlier study we demonstrated that Concanavalin-A stimulated bovine T cell supernatants inhibited the growth of Cowdria ruminantium in bovine endothelial cells in vitro. An investigation was conducted to identify the cytokines which were responsible for this growth inhibition. Addition of antiserum against bovine interferon gamma (IFN gamma) reproducibly neutralized the inhibitory effect of the T cell supernatants, whereas addition of antisera against bovine tumor necrosis factor alpha (TNF alpha) had no effect. The inhibitory effect of IFN gamma on C. ruminantium growth was not mediated by the production of nitric oxide as there was no detectable difference in nitric oxide levels in cultures that were supplemented with T cell supernatants compared with those that were not. The IFN gamma mediated anti-C. ruminantium effect highlights the importance of cell mediated immune responses in control of these infections and in particular incriminates the protective role of T cells, or cells that secrete IFN gamma.

摘要

在早期的一项研究中,我们证明了伴刀豆球蛋白A刺激的牛T细胞上清液在体外可抑制反刍兽无形体在牛内皮细胞中的生长。我们进行了一项研究,以确定导致这种生长抑制的细胞因子。添加抗牛γ干扰素(IFNγ)抗血清可重复性地中和T细胞上清液的抑制作用,而添加抗牛肿瘤坏死因子α(TNFα)抗血清则没有效果。IFNγ对反刍兽无形体生长的抑制作用不是由一氧化氮的产生介导的,因为与未添加T细胞上清液的培养物相比,添加了T细胞上清液的培养物中一氧化氮水平没有可检测到的差异。IFNγ介导的抗反刍兽无形体作用突出了细胞介导的免疫反应在控制这些感染中的重要性,特别是揭示了T细胞或分泌IFNγ的细胞的保护作用。

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