Dean D A, Mangold B L, Harrison R A, Ricciardone M D
US Naval Medical Unit No. 3, Cario, Egypt.
Parasite Immunol. 1996 Aug;18(8):403-10. doi: 10.1046/j.1365-3024.1996.d01-129.x.
C57BL/6 and Balb/c mice were immunized with ultraviolet-irradiated cercariae of Egyptian strains of Schistosoma mansoni and S. haematobium, challenged with nonirradiated cercariae of the homologous or heterologous species, and assayed for protection against challenge infection by comparing the adult worm burdens of immunized and non-immunized mice. Homologous protection (per cent reduction in worm recovery) ranged from 56% to 69% for S. mansoni and 88% to 99% for S. haematobium. Significant heterologous protection was consistently induced against S. haematobium by immunization with S. mansoni, but not against S. mansoni by immunization with S. haematobium. These results are discussed in relation to those of previous studies and in terms of implications for vaccine development.
将C57BL/6和Balb/c小鼠用埃及株曼氏血吸虫和埃及血吸虫的紫外线照射尾蚴进行免疫，然后用同源或异源物种的未照射尾蚴进行攻击，并通过比较免疫小鼠和未免疫小鼠的成虫负荷来测定对攻击感染的保护作用。曼氏血吸虫的同源保护（虫体回收率降低百分比）范围为56%至69%，埃及血吸虫为88%至99%。用曼氏血吸虫免疫可始终诱导出对埃及血吸虫的显著异源保护，但用埃及血吸虫免疫则不能诱导出对曼氏血吸虫的异源保护。结合先前研究的结果并从疫苗开发的意义方面对这些结果进行了讨论。
