Braghiroli L, Ponzianelli A, Fiani M, De Feo G, Cheng C Y, Mazzanti G
Institute of Pharmacology and Pharmacognosy, University of Rome La Sapienza, Italy.
Pharmacol Res. 1997 Mar;35(3):173-5. doi: 10.1006/phrs.1996.0102.
Although the atypical antipsychotic agent clozapine has little propensity to induce hyperprolactinemia in humans it increases serum prolactin levels in the rat. In this study, the effects of clozapine and of some typical antipsychotic drugs on basal and dopamine-mediated prolactin secretion from cultured rat pituitary cells were compared. Despite being less potent than the other antipsychotic agents tested, clozapine reverted the effect of dopamine on prolactin secretion in vitro. This finding suggests that clozapine interferes with dopamine receptors in the pituitary gland.
尽管非典型抗精神病药物氯氮平在人体内几乎没有诱发高催乳素血症的倾向，但它会使大鼠的血清催乳素水平升高。在本研究中，比较了氯氮平和一些典型抗精神病药物对培养的大鼠垂体细胞基础催乳素分泌及多巴胺介导的催乳素分泌的影响。尽管氯氮平的效力低于所测试的其他抗精神病药物，但它在体外逆转了多巴胺对催乳素分泌的作用。这一发现表明氯氮平会干扰垂体中的多巴胺受体。
