[Effect of cations of transition metals on respiration and H+ production in liver mitochondria].

Results obtained prove that respiration stimulation of mitochondria Ca2+, Sr2+, Mn2+ is determined by transport of these cations to the indicated subcellular structures with participation of Ca2(+)-uniporter. Effect of Cd2+ on respiration of mitochondria is of two-phase character. Concentration of Cd2+ being above 100 microM the stimulation phase is accompanied by the further inhibition of mitochondria respiration. La3+ inhibits respiration of mitochondria. However La3+ and Cd2+ stimulate H+ production by mitochondria, that is not blocked by ruthenium red (10 microM). Probably, the effect of La3+ and Cd2+ on respiration of mitochondria is determined by the change of proton conductivity of mitochondrion membrane. Direct inhibiting effect of Cd2+ on the respiration chain of mitochondria has been established.