Maksić D, Marić M, Mijusković Z, Dimitrijević J, Kovacević Z, Jovanović D
Vojnomedicinska akademija, Klinika za nefrologiju, Centralna klinicko-hemijska laboratorija, Institut za patologiju i sudsku medicinu, Beograd.
Vojnosanit Pregl. 1996 Jul-Aug;53(4):293-6.
The aim of this study was to prove the increased IgA1 production in patients with IgA nephropathy compared to the control group of healthy subjects, by determination of serum subclasses IgA, IgA1 and IgA2 levels. That with the exclusive presence of IgA1 in kidney tissue, justified the assertion that IgAN was IgA1 disease. Eighteen patients with IgA nephropathy, 15 male and 3 female, average age 17-54 (mean +/- SD = 34.1 +/- 5.18) were included in the prospective study. The diagnosis was proved by immunofluorescent assay of bioptic kidney material obtained by ultrasonically guided biopsy. The total serum IgA and IgA1 and IgA2 subclasses levels were determined in the patients and healthy conscripts from the control group. The methods of immunonephelometry and radial immunodiffusion were used. Increased IgA values were found in 22.75% and of IgA1 subclass in 38.85% patients. Patients with IgA nephropathy had significantly higher IgA1 values (p < 0.01), compared to the control group. There was no significant difference in IgA2 subclass levels. Renal function did not significantly affect IgA1 and IgA2 subclasses values.
本研究的目的是通过测定血清IgA、IgA1和IgA2亚类水平，证明与健康对照人群相比，IgA肾病患者的IgA1产生增加。鉴于肾组织中仅存在IgA1，这证明了IgA肾病是IgA1疾病这一论断。18例IgA肾病患者（15例男性，3例女性，平均年龄17 - 54岁，平均±标准差 = 34.1±5.18）被纳入前瞻性研究。诊断通过超声引导下活检获取的肾活检材料的免疫荧光测定得以证实。测定了患者及对照组健康应征者的血清总IgA、IgA1和IgA2亚类水平。采用免疫比浊法和单向免疫扩散法。22.75%的患者IgA值升高，38.85%的患者IgA1亚类升高。与对照组相比，IgA肾病患者的IgA1值显著更高（p < 0.01）。IgA2亚类水平无显著差异。肾功能对IgA1和IgA2亚类值无显著影响。
