Levine T B, Levine A B, Vincenzi A, Keteyian S J, Billings J, Lesch M
Division of Cardiology, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Am J Cardiol. 1997 Jul 15;80(2):212-4. doi: 10.1016/s0002-9149(97)00322-6.
To determine the cardiovascular protective effects of angiotensin-converting enzyme inhibitors, we examined the response to intensive vasodilator therapy in patients with ischemic cardiomyopathy and ongoing angina pectoris. We found that for patients with ischemic cardiomyopathy and ongoing active angina, intensive vasodilator therapy with angiotensin-converting enzyme inhibition and nitrates improved not only heart failure-related symptoms, but also resulted in a significant improvement in symptomatic ischemia and ischemia-related morbid events.
为了确定血管紧张素转换酶抑制剂对心血管的保护作用，我们研究了缺血性心肌病和持续性心绞痛患者对强化血管扩张剂治疗的反应。我们发现，对于患有缺血性心肌病和持续性活动性心绞痛的患者，采用血管紧张素转换酶抑制和硝酸盐进行强化血管扩张剂治疗不仅改善了与心力衰竭相关的症状，而且还显著改善了症状性缺血和与缺血相关的不良事件。
