工频磁场不会促进JB6细胞的转化。
Power frequency magnetic fields do not contribute to transformation of JB6 cells.
作者信息
Saffer J D, Chen G, Colburn N H, Thurston S J
机构信息
Molecular Biosciences Department, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
出版信息
Carcinogenesis. 1997 Jul;18(7):1365-70. doi: 10.1093/carcin/18.7.1365.
The potential for power frequency magnetic fields to enhance neoplastic transformation has been investigated in vitro using promotion-sensitive mouse epidermal JB6 cells. In a soft agar assay, 60-Hz magnetic fields of 0.01, 0.1, 1.0, or 1.1 mT flux density did not induce anchorage-independent growth. In addition, these magnetic fields did not enhance tumor promoter-induced transformation showing no increase in the maximum number of transformed colonies and no shift in the dose-response curve. Thus, these data do not support the notion that environmental exposures to magnetic fields contribute to transformation.
利用对促癌敏感的小鼠表皮JB6细胞，在体外研究了工频磁场增强肿瘤转化的可能性。在软琼脂试验中，通量密度为0.01、0.1、1.0或1.1 mT的60 Hz磁场未诱导非贴壁依赖性生长。此外，这些磁场并未增强肿瘤启动子诱导的转化，未显示转化集落的最大数量增加，剂量反应曲线也未发生偏移。因此，这些数据不支持环境暴露于磁场会导致转化这一观点。
Zotero 插件