檀香气味剂的构效关系：β-甲基檀香醇的合成与气味
Structure-activity relationships of sandalwood odorants: synthesis and odour of methyl-beta-santalol.
作者信息
Buchbauer G, Zechmeister-Machhart F, Weiss-Greiler P, Wolschann P
机构信息
Institute of Pharmaceutical Chemistry, University of Vienna, Austria.
出版信息
Arch Pharm (Weinheim). 1997 Apr;330(4):112-4. doi: 10.1002/ardp.19973300407.
The synthesis and odour properties of the new santalol analogue, methyl-beta-santalol, are described. The additional methyl group adjacent to the hydroxyl function of the standard molecule, beta-santalol, deprives the new compound of the sandalwood note. The synthesis and the odour evaluation of this compound supports the proposed model for sandalwood fragrance as it shows that the methyl group located at the osmophoric center prevents association of the molecule with the hypothetical receptor.
描述了新型檀香醇类似物甲基-β-檀香醇的合成及其气味特性。与标准分子β-檀香醇的羟基相邻的额外甲基使新化合物失去了檀香味。该化合物的合成及气味评估支持了所提出的檀香香气模型，因为它表明位于发香中心的甲基阻止了分子与假想受体的缔合。
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