Trifiletti A, Scamardi R, Pizzoleo M A, Nevoso A, Attina A, Soraci S, Bagnato L, Barbera N
Chair of Angiology, Department of Internal Medicine, University of Messina, Italy.
Panminerva Med. 1997 Jun;39(2):100-2.
In twenty patients with primitive venous hypertension and in ten healthy subjects we have determined the plasmatic levels of: Thrombomodulin (TM), beta-Thromboglobulin (beta-TG), D-Dimer (DD), the tissue activator of the plasminogen (t-PA) and the inhibitor of the activator of the plasminogen (PAI-1). The levels of the parameter we studied have shown in the patients a significant difference of beta-TG (p < 0.01) and PAI-1 (p < 0.01) compared to the controls, whereas there was no significant difference in the other parameters we studied. Our data underline, in patients with primitive venous hypertension, the importance that the activation of the platelets and the reduction of the potential fibrinolytic can assume, together with the stasis, regarding the onset of thrombotic complications.
在20例原发性静脉高压患者和10名健康受试者中，我们测定了以下血浆水平：血栓调节蛋白（TM）、β-血小板球蛋白（β-TG）、D-二聚体（DD）、纤溶酶原组织激活剂（t-PA）和纤溶酶原激活剂抑制剂（PAI-1）。与对照组相比，我们研究的参数水平在患者中显示出β-TG（p < 0.01）和PAI-1（p < 0.01）有显著差异，而我们研究的其他参数则无显著差异。我们的数据强调，在原发性静脉高压患者中，血小板激活和纤溶潜能降低与血流淤滞一起，对于血栓形成并发症的发生具有重要意义。
