Fukuda M, Mikoshiba K
Molecular Neurobiology Laboratory, Tsukuba Life Science Center, Ibaraki, Japan.
Bioessays. 1997 Jul;19(7):593-603. doi: 10.1002/bies.950190710.
The inositol phosphate metabolism network has been found to be much more complex than previously thought, as more and more inositol phosphates and their metabolizing enzymes have been discovered. Some of the inositol phosphates have been shown to have biological activities, but little is known about their signal transduction mechanisms except for that of inositol 1,4,5-trisphosphate. The recent discovery, however, of a number of binding proteins for inositol high polyphosphate [inositol 1,3,4,5-tetrakisphosphate (IP4), inositol 1,3,4,5,6-pentakisphosphate, or inositol hexakisphosphate] enables us to speculate on the physiological function of these compounds. In this article we focus on two major issues: (1) the roles of inositol high polyphosphates in vesicular trafficking, especially exocytosis, and (2) pleckstrin homology domain-containing IP4 binding proteins involved in the Ras signaling pathway.
随着越来越多的肌醇磷酸及其代谢酶被发现，人们发现肌醇磷酸代谢网络比之前认为的要复杂得多。一些肌醇磷酸已被证明具有生物活性，但除了肌醇1,4,5-三磷酸外，对其信号转导机制了解甚少。然而，最近发现了许多肌醇高聚磷酸[肌醇1,3,4,5-四磷酸（IP4）、肌醇1,3,4,5,6-五磷酸或肌醇六磷酸]的结合蛋白，这使我们能够推测这些化合物的生理功能。在本文中，我们关注两个主要问题：（1）肌醇高聚磷酸在囊泡运输，尤其是胞吐作用中的作用，以及（2）参与Ras信号通路的含pleckstrin同源结构域的IP4结合蛋白。
