Muriana F J, Villar J, Ruíz-Gutiérrez V
Instituto de la Grasa, CSIC, Seville, Spain.
Cell Mol Life Sci. 1997 Jun;53(6):496-500. doi: 10.1007/s000180050061.
Transbilayer movement of erythrocyte membrane cholesterol is impaired in patients affected with essential hypertension. This is an inherited disorder, but environmental factors are also involved. Dietary fats might play a role in the prevention and/or treatment of such abnormality in the kinetic pools of membrane cholesterol. We tested this hypothesis by using a diet (in which 30% of the energy came from fat) rich in olive oil or in high-oleic sunflower oil (as natural sources of monounsaturated fatty acids, MUFAs) and determining their influence on the movement of cholesterol into the lipid bilayer of the erythrocyte membrane after a four-week period. We concluded that dietary olive oil is helpful in normalizing the impaired transbilayer movement of membrane cholesterol in erythrocytes of eight normocholesterolaemic and eight hypercholesterolaemic hypertensive patients. However, the effects cannot be attributed exclusively to the content of MUFAs (mainly oleic acid) in the diet, as high-oleic sunflower oil was unable to induce favourable changes.
原发性高血压患者红细胞膜胆固醇的跨膜运动受损。这是一种遗传性疾病，但也涉及环境因素。膳食脂肪可能在预防和/或治疗膜胆固醇动力学池的这种异常中发挥作用。我们通过使用一种饮食（其中30%的能量来自脂肪）来检验这一假设，该饮食富含橄榄油或高油酸葵花籽油（作为单不饱和脂肪酸的天然来源），并在四周后确定它们对胆固醇进入红细胞膜脂质双层运动的影响。我们得出结论，膳食橄榄油有助于使8名正常胆固醇血症和8名高胆固醇血症高血压患者红细胞膜中受损的胆固醇跨膜运动正常化。然而，这些作用不能完全归因于饮食中单一不饱和脂肪酸（主要是油酸）的含量，因为高油酸葵花籽油无法诱导出有利的变化。
