Kamiya Y, Mtitimila E, Graham S M, Broadhead R L, Brabin B, Hart C A
Tropical Child Health Group, Liverpool School of Tropical Medicine, University of Liverpool, UK.
Ann Trop Paediatr. 1997 Jun;17(2):121-6. doi: 10.1080/02724936.1997.11747874.
Sixty children aged between 1 and 23 months admitted to Queen Elizabeth Central Hospital in Blantyre, Malawi for diagnosis of acute lower respiratory tract infections (ALRI) were investigated for laboratory diagnosis of Pneumocystis carinii pneumonia (PCP) by indirect immunofluorescence assay on nasopharyngeal secretions. P. carinii was found in five of the 60 children. Three PCP cases had AIDS. The clinical presentation of children with PCP was of little diagnostic value and all the children were infants. Arterial oxygen saturation was significantly lower in PCP cases. Of the five PCP cases, four died, indicating that the marked hypoxaemia was associated with poor prognosis. These results indicate that an immunofluorescence assay on nasopharyngeal secretions could be used for first-line diagnosis of PCP in Africa.
对马拉维布兰太尔伊丽莎白女王中央医院收治的60名年龄在1至23个月之间、因急性下呼吸道感染（ALRI）入院诊断的儿童，通过对鼻咽分泌物进行间接免疫荧光检测，调查卡氏肺孢子虫肺炎（PCP）的实验室诊断情况。60名儿童中有5名检测出卡氏肺孢子虫。3例PCP病例患有艾滋病。PCP患儿的临床表现诊断价值不大，且所有患儿均为婴儿。PCP病例的动脉血氧饱和度显著较低。5例PCP病例中有4例死亡，表明明显的低氧血症与预后不良相关。这些结果表明，对鼻咽分泌物进行免疫荧光检测可用于非洲PCP的一线诊断。
