电休克治疗对内源性抑郁症患者色氨酸代谢及分布无早期影响。

No early effects of electroconvulsive therapy on tryptophan metabolism and disposition in endogenous depression.

作者信息

Mokhtar A S, Morgan C J, Bradley D M, Badawy A A

机构信息

Cardiff Community Healthcare NHS Trust, Biomedical Research Laboratory, Whitchurch Hospital, Cardiff, Wales, United Kingdom.

出版信息

Biol Psychiatry. 1997 Aug 1;42(3):201-5. doi: 10.1016/S0006-3223(96)00336-8.

DOI:10.1016/S0006-3223(96)00336-8

PMID:9232212

Abstract

The possibility that a single electroconvulsive therapy (ECT) could increase tryptophan (Trp) availability to the brain for 5-hydroxytryptamine (5-HT, serotonin) synthesis was examined in 10 depressed patients before and during the 1st hour following an ECT and in 4 control (minor ear, nose, and throat surgical) subjects receiving similar premedication. Trp availability to the brain, expressed as the serum Trp: competing amino acid ratio, and related aspects of Trp disposition were not significantly altered by ECT any differently than from preoperative stress and premedication. We suggest that Trp availability to the brain and, hence, cerebral 5-HT synthesis are not altered in depressed patients early after a single ECT.

摘要

在10名抑郁症患者接受电休克治疗（ECT）前及治疗后第1小时内，以及4名接受类似术前用药的对照（耳鼻喉小手术）受试者中，研究了单次ECT是否能增加大脑中色氨酸（Trp）的可用性以用于5-羟色胺（5-HT，血清素）合成。大脑中Trp的可用性以血清Trp与竞争性氨基酸的比值表示，Trp处置的相关方面在ECT后与术前应激和术前用药相比，并没有显著差异。我们认为，单次ECT后早期，抑郁症患者大脑中Trp的可用性以及由此产生的大脑5-HT合成并未改变。