用于咳嗽反射和镇咳药研究的吸入性咳嗽激发试验

Inhalation cough challenge in the investigation of the cough reflex and antitussives.

作者信息

Morice A H

机构信息

Department of Medicine and Pharmacology, Royal Hallamshire Hospital, Sheffield, UK.

出版信息

Pulm Pharmacol. 1996 Oct-Dec;9(5-6):281-4. doi: 10.1006/pulp.1996.0036.

DOI:10.1006/pulp.1996.0036

PMID:9232664

Abstract

Inhalation cough challenge is a useful tool in the physiological and pharmacological investigation of the cough reflex. There are three types of challenge used, capsaicin and the vanilloids, organic acids, and distilled water challenge. In addition, challenge may be administered in a single dose or cumulative dose fashion. The correct combination of inhalation technology and tussive stimulus produces a sensitive and specific method for estimating the cough reflex.

摘要

吸入性咳嗽激发试验是咳嗽反射生理和药理研究中的一种有用工具。使用的激发试验有三种类型，即辣椒素和香草酸类、有机酸以及蒸馏水激发试验。此外，激发试验可以单剂量或累积剂量的方式给药。吸入技术和咳嗽刺激的正确组合产生了一种评估咳嗽反射的灵敏且特异的方法。