神经元基因表达中的钙离子依赖性调控。
Ca2+-dependent regulation in neuronal gene expression.
作者信息
Bito H, Deisseroth K, Tsien R W
机构信息
Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo-ku, Kyoto 606-01, Japan.
出版信息
Curr Opin Neurobiol. 1997 Jun;7(3):419-29. doi: 10.1016/s0959-4388(97)80072-4.
PMID:9232807
Abstract
Ca2+ is an important signal-transduction molecule that plays a role in many intracellular signaling pathways. Recent advances have indicated that in neurons, Ca2+-controlled signaling mechanisms cooperate in order to discriminate amongst incoming cellular inputs. Ca2+-dependent transcriptional events can thereby be made selectively responsive to bursts of synaptic activity of specific intensity or duration.
摘要
钙离子（Ca2+）是一种重要的信号转导分子，在许多细胞内信号通路中发挥作用。最近的研究进展表明，在神经元中，钙离子控制的信号机制协同作用，以便区分传入的细胞输入信号。由此，依赖钙离子的转录事件能够对特定强度或持续时间的突触活动爆发做出选择性反应。
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