• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Fluorescence study of neurohypophyseal hormones and their analogues. Distance distributions in a series of arginine-vasopressin analogues.神经垂体激素及其类似物的荧光研究。一系列精氨酸加压素类似物中的距离分布。
Eur Biophys J. 1997;26(2):183-93. doi: 10.1007/s002490050070.
2
Distance distributions from the tyrosyl to disulfide residues in the oxytocin and [Arg8]-vasopressin measured using frequency-domain fluorescence resonance energy transfer.使用频域荧光共振能量转移测量的催产素和[精氨酸8]-加压素中酪氨酸残基与二硫键残基之间的距离分布。
Eur Biophys J. 1996;24(3):185-93. doi: 10.1007/BF00180276.
3
Exploration of the conformational space of oxytocin and arginine-vasopressin using the electrostatically driven Monte Carlo and molecular dynamics methods.使用静电驱动蒙特卡罗和分子动力学方法探索催产素和精氨酸加压素的构象空间。
Biopolymers. 1996 Feb;38(2):157-75. doi: 10.1002/(sici)1097-0282(199602)38:2<157::aid-bip3>3.0.co;2-u.
4
Synthesis and some pharmacological properties of 18 potent O-alkyltyrosine-substituted antagonists of the vasopressor responses to arginine-vasopressin.18种强效的O-烷基酪氨酸取代的精氨酸加压素血管升压反应拮抗剂的合成及某些药理特性
J Med Chem. 1985 Oct;28(10):1485-91. doi: 10.1021/jm00148a019.
5
Theoretical conformational analysis of three vasopressin antagonists with a modified cyclohexyl ring in the first thioacid residue.对三种在首个硫代酸残基中具有修饰环己基环的血管加压素拮抗剂进行的理论构象分析。
Int J Pept Protein Res. 1995 May;45(5):451-8. doi: 10.1111/j.1399-3011.1995.tb01060.x.
6
Synthesis and some pharmacological properties of oxytocin and vasopressin analogues with sarcosine or N-methyl-L-alanine in position 7.第7位含肌氨酸或N-甲基-L-丙氨酸的催产素和加压素类似物的合成及某些药理性质
J Med Chem. 1983 Apr;26(4):555-9. doi: 10.1021/jm00358a018.
7
Arginine-vasopressin analogues with high antidiuretic/vasopressor selectivity. Synthesis, biological activity, and receptor binding affinity of arginine-vasopressin analogues with substitutions in positions 1, 2, 4, 7, and 8.具有高抗利尿/血管升压选择性的精氨酸加压素类似物。1、2、4、7和8位有取代的精氨酸加压素类似物的合成、生物活性及受体结合亲和力。
J Med Chem. 1986 Jan;29(1):96-9. doi: 10.1021/jm00151a016.
8
Potent antagonists of the antidiuretic responses to arginine-vasopressin based on modifications of [1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid),2-D- phenylalanine,4-valine]arginine-vasopressin at position 4.基于对[1-(β-巯基-β,β-环戊亚甲基丙酸),2-D-苯丙氨酸,4-缬氨酸]精氨酸加压素4位进行修饰而得到的对精氨酸加压素抗利尿反应的强效拮抗剂。
J Med Chem. 1983 Nov;26(11):1607-13. doi: 10.1021/jm00365a011.
9
Analogues of neurohypophyseal hormones, oxytocin and arginine vasopressin, conformationally restricted in the N-terminal part of the molecule.神经垂体激素（催产素和精氨酸加压素）的类似物，在分子的N端部分具有构象限制。
J Med Chem. 2006 Mar 23;49(6):2016-21. doi: 10.1021/jm058038f.
10
Position three in vasopressin antagonist tolerates conformationally restricted and aromatic amino acid substitutions: a striking contrast with vasopressin agonists.血管加压素拮抗剂中的第三个位置能耐受构象受限的和芳香族氨基酸取代：这与血管加压素激动剂形成了显著对比。
J Pept Sci. 1997 Jan-Feb;3(1):31-46. doi: 10.1002/(sici)1099-1387(199701)3:1<31::aid-psc82>3.0.co;2-y.

本文引用的文献

1
Transient Effects in Fluorescence Quenching Measured by 2-GHz Frequency-Domain Fluorometry.通过2-GHz频域荧光测定法测量荧光猝灭中的瞬态效应。
J Phys Chem. 1987 Jun;91(12):3277-3285. doi: 10.1021/j100296a035.
2
End-to-End Diffusion and Distance Distributions of Flexible Donor-Acceptor Systems Observed by Intramolecular Energy Transfer and Frequency-Domain Fluorometry; Enhanced Resolution by Global Analysis of Externally Quenched and Nonquenched Samples.通过分子内能量转移和频域荧光法观察柔性供体-受体系统的端到端扩散和距离分布；通过对外部猝灭和未猝灭样品的全局分析提高分辨率。
J Phys Chem. 1991 Nov 1;95(24):9654-9660. doi: 10.1021/j100177a012.
3
Conformational differences of oxytocin and vasopressin as observed by fluorescence anisotropy decays and transient effects in collisional quenching of tyrosine fluorescence.通过荧光各向异性衰减和酪氨酸荧光碰撞猝灭中的瞬态效应观察到的催产素和血管升压素的构象差异。
J Fluoresc. 1991 Sep;1(3):163-76. doi: 10.1007/BF00865363.
4
Distance distributions from the tyrosyl to disulfide residues in the oxytocin and [Arg8]-vasopressin measured using frequency-domain fluorescence resonance energy transfer.使用频域荧光共振能量转移测量的催产素和[精氨酸8]-加压素中酪氨酸残基与二硫键残基之间的距离分布。
Eur Biophys J. 1996;24(3):185-93. doi: 10.1007/BF00180276.
5
Exploration of the conformational space of oxytocin and arginine-vasopressin using the electrostatically driven Monte Carlo and molecular dynamics methods.使用静电驱动蒙特卡罗和分子动力学方法探索催产素和精氨酸加压素的构象空间。
Biopolymers. 1996 Feb;38(2):157-75. doi: 10.1002/(sici)1097-0282(199602)38:2<157::aid-bip3>3.0.co;2-u.
6
Conformational distributions of a four-way DNA junction revealed by time-resolved fluorescence resonance energy transfer.通过时间分辨荧光共振能量转移揭示的四链 DNA 连接体的构象分布
Biochemistry. 1993 Dec 21;32(50):13852-60. doi: 10.1021/bi00213a014.
7
Fluorescence quenching studies with proteins.蛋白质的荧光猝灭研究。
Anal Biochem. 1981 Jul 1;114(2):199-227. doi: 10.1016/0003-2697(81)90474-7.
8
Conformational energy studies on N-methylated analogs of thyrotropin releasing hormone, enkephalin, and luteinizing hormone-releasing hormone.促甲状腺激素释放激素、脑啡肽和促黄体生成素释放激素的N-甲基化类似物的构象能研究。
Biopolymers. 1980 Nov;19(11):1943-73. doi: 10.1002/bip.1980.360191103.
9
Acrylamide fluorescence quenching applied to tyrosyl residues in proteins.丙烯酰胺荧光猝灭应用于蛋白质中的酪氨酸残基。
Photochem Photobiol. 1983 Sep;38(3):373-6. doi: 10.1111/j.1751-1097.1983.tb02686.x.
10
Influence of sarcosine or N-methylalanine in position 7 on the antagonistic properties of [1-deaminopenicillamine]- and [1-(beta-mercapto-beta, beta-cyclopentylmethylene-propionic acid)]-vasopressin.7位肌氨酸或N-甲基丙氨酸对[1-脱氨青霉胺]-和[1-(β-巯基-β,β-环戊基亚甲基丙酸)]-加压素拮抗特性的影响。
Int J Pept Protein Res. 1984 Jan;23(1):78-83. doi: 10.1111/j.1399-3011.1984.tb02695.x.

神经垂体激素及其类似物的荧光研究。一系列精氨酸加压素类似物中的距离分布。

Fluorescence study of neurohypophyseal hormones and their analogues. Distance distributions in a series of arginine-vasopressin analogues.

作者信息

Wiczk W, Lankiewicz L, Kasprzykowski F, Ołdziej S, Szmaciński H, Lakowicz J R, Grzonka Z

机构信息

Faculty of Chemistry, University of Gdańsk, Poland.

出版信息

Eur Biophys J. 1997;26(2):183-93. doi: 10.1007/s002490050070.

DOI:10.1007/s002490050070
PMID:9232846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6884421/
Abstract

Analogues of arginine-vasopressin (AVP) in which substitution of the proline residue in position 7 (by either sarcosine or N-methylalanine) combined with replacement of the cysteine residue in position 1 were the subject of a fluorescence and molecular mechanics study. We obtained two groups of analogues: selective antidiuretic agonists (cysteine or beta-mercaptopropionic acid in position 1) and pressor and uterotonic antagonists (deaminopenicillamine or beta-mercapto-beta, beta-cyclopentamethylenepropionic acid in position 1). Using frequency-domain measurements of fluorescence resonance energy transfer (FRET) we estimated the distance distribution between the phenolic ring of Tyr2 and the disulphide bridge Cys1-Cys6. We also analyzed acrylamide quenching of tyrosyl fluorescence to determine the exposure of the tyrosyl ring to the solvent. Results from fluorescence experiments were compared with those from Monte Carlo simulation (ECEPP/3 force-field).

摘要

精氨酸加压素（AVP）的类似物，其中第7位脯氨酸残基被肌氨酸或N-甲基丙氨酸取代，并结合第1位半胱氨酸残基的替换，是荧光和分子力学研究的对象。我们获得了两组类似物：选择性抗利尿激动剂（第1位为半胱氨酸或β-巯基丙酸）和升压及子宫收缩拮抗剂（第1位为脱氨青霉胺或β-巯基-β，β-环戊亚甲基丙酸）。使用荧光共振能量转移（FRET）的频域测量，我们估计了Tyr2酚环与二硫键Cys1-Cys6之间的距离分布。我们还分析了丙烯酰胺对酪氨酸荧光的淬灭，以确定酪氨酸环对溶剂的暴露情况。荧光实验结果与蒙特卡罗模拟（ECEPP/3力场）结果进行了比较。