Rush C R, Griffiths R R
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, USA.
Exp Clin Psychopharmacol. 1997 Feb;5(1):28-38. doi: 10.1037//1064-1297.5.1.28.
The acute behavioral effects of buspirone (15 and 30 mg/70 kg), alprazolam (0.75 and 1.5 mg/70 kg), and placebo, alone and in combination with ethanol (0-0.6 g/kg), were tested in 13 volunteers. Ethanol alone produced only a few significant behavioral effects. Alprazolam and buspirone produced comparable dose-related increases in participant ratings of sedation, but only alprazolam impaired performance. The buspirone-ethanol and alprazolam-ethanol combinations produced robust sedative-like participant-related drug effects that were similar in magnitude, but, in general, only the alprazolam-ethanol combinations impaired performance. These findings suggest that the participant-rated effects of therapeutic doses of buspirone in combination with moderate doses of ethanol are similar to those of therapeutic doses of alprazolam in combination with ethanol, but the performance-impairing effects of buspirone are distinguishable from those of alprazolam, alone and in combination with ethanol.
在13名志愿者身上测试了丁螺环酮（15毫克/70千克和30毫克/70千克）、阿普唑仑（0.75毫克/70千克和1.5毫克/70千克）以及安慰剂单独使用时，以及与乙醇（0 - 0.6克/千克）联合使用时的急性行为效应。单独使用乙醇仅产生了一些显著的行为效应。阿普唑仑和丁螺环酮在参与者的镇静评分上产生了类似剂量相关的增加，但只有阿普唑仑会损害表现。丁螺环酮 - 乙醇组合和阿普唑仑 - 乙醇组合产生了强烈的类似镇静的与参与者相关的药物效应，其程度相似，但一般来说，只有阿普唑仑 - 乙醇组合会损害表现。这些发现表明，治疗剂量的丁螺环酮与中等剂量乙醇联合使用时，参与者评定的效应与治疗剂量的阿普唑仑与乙醇联合使用时相似，但丁螺环酮对表现的损害效应与阿普唑仑单独使用以及与乙醇联合使用时的效应有所不同。
