Lamb R J, Järbe T U
Department of Psychiatry, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102-1192, USA.
Exp Clin Psychopharmacol. 1997 May;5(2):123-9. doi: 10.1037//1064-1297.5.2.123.
The effects of saccharin concentration on the stimulus control by a compound stimulus consisting of morphine, saccharin (0.01, 0.03, or 0.10%, wt/vol), and a ball bearing drinking nozzle in a discriminated taste aversion (DTA) procedure were examined in rats (Rattus norvegicus). In paired rats injections of lithium followed presentation of this compound stimulus, whereas in unpaired rats saline injections followed this stimulus. DTA acquisition was more rapid at higher saccharin concentrations. In testing with each individual stimulus element, stimulus control was clearly exerted by all 3 stimulus elements. When another stimulus element was presented jointly with saccharin, behavioral control was similar to that of saccharin alone. Behavioral control by saccharin increased with saccharin concentration. However, behavioral control by the 2 other stimulus elements was relatively unaffected when the saliency of the saccharin element was increased.
在大鼠（褐家鼠）中，采用辨别性味觉厌恶（DTA）程序，研究了糖精浓度对由吗啡、糖精（0.01%、0.03%或0.10%，重量/体积）和滚珠饮水嘴组成的复合刺激的刺激控制作用。在配对大鼠中，给予锂注射后再呈现该复合刺激，而在非配对大鼠中，给予生理盐水注射后再呈现该刺激。在较高糖精浓度下，DTA习得更快。在对每个单独刺激元素进行测试时，所有3个刺激元素都能明显发挥刺激控制作用。当另一个刺激元素与糖精共同呈现时，行为控制与单独使用糖精时相似。糖精的行为控制作用随糖精浓度增加而增强。然而，当糖精元素的显著性增加时，其他两个刺激元素的行为控制作用相对不受影响。
