Hackstadt T, Fischer E R, Scidmore M A, Rockey D D, Heinzen R A
Host-Parasite Interactions Section, National Institute of Allergy and Infections Diseases, NIH, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
Trends Microbiol. 1997 Jul;5(7):288-93. doi: 10.1016/S0966-842X(97)01061-5.
Chlamydiae dissociate themselves from the endocytic pathway shortly after internalization by actively modifying the vacuole to become fusogenic with sphingomyelin-containing exocytic vesicles. Interaction with this secretory pathway appears to provide a pathogenic mechanism that allows chlamydiae to establish themselves in a site that is not destined to fuse with lysosomes.
衣原体在被内化后不久，通过积极修饰液泡使其与含鞘磷脂的分泌小泡发生融合，从而使其自身脱离内吞途径。与该分泌途径的相互作用似乎提供了一种致病机制，使衣原体能够在一个不会与溶酶体融合的位点定植。
