Ciutică I, Bastides F, Besnier M, Barin F, Choutet P
Clinica de Boli Infecţioase, UMF Cluj Napoca, România.
Bacteriol Virusol Parazitol Epidemiol. 1997 Jan-Jun;42(1-2):59-63.
The authors study the reactivation of B hepatitis virus in three HIV infected patients, correlating the moment of reactivation of and the CD4 and CD8 lymphocytes. Prior to the B viral reactivation, the three patients were with Ac HBc IgG (+) in serum, assessing that the presence of AC HBc IgG is insufficient to prevent the reactivation and to consider a B hepatitis cured. In two patients, prior to the B virus reactivation, AgHBs was (-) in the serum. It is considered that the predominant hepatocytolysis mechanism is the viral one, in the stage of B virus reactivation in patients with AIDS, the cell immunity mechanism being depressed.
作者研究了3例HIV感染患者中乙型肝炎病毒的再激活情况,并将其与再激活时间以及CD4和CD8淋巴细胞进行关联分析。在乙型肝炎病毒再激活之前,这3例患者血清中抗-HBc IgG均为阳性,提示抗-HBc IgG的存在不足以预防病毒再激活,也不能认定乙型肝炎已治愈。在2例患者中,乙型肝炎病毒再激活之前血清中HBsAg为阴性。据认为,在艾滋病患者乙型肝炎病毒再激活阶段,主要的肝细胞溶解机制是病毒机制,此时细胞免疫机制受到抑制。