Almárcegui Lafita C, Fernandez Tirado J, Melcon Sanchez Friera B, Uclés Moreno P, Valdizán Usón J R, Honrubia López F M
Service de neurophysiologie clinique, hôpital Miguel Servert, Saragasse, Espagne.
Neurophysiol Clin. 1997;27(2):109-15. doi: 10.1016/s0987-7053(97)85663-8.
Current electrophysiological techniques that help guide the diagnosis of glaucoma include pattern-electroretinogram (PERG) and pattern-visual evoked potential (PEVP) recordings. However, PERG has been recognized over the last decade as a good indicator of retinal ganglion cell function. One hundred seventy one eyes corresponding to 89 subjects were studied using both PERG (gold foil electrodes) and PEVP recordings. Two groups respectively including 32 subjects with ocular hypertension (OHT) and 27 subjects with simple chronic glaucoma (SCG) were compared with a control group composed of 30 healthy age-matched subjects. In regard to PERG recordings, the amplitudes of the P50 and N95 components were measured, but statistically significant differences were shown only for the N95 amplitudes both SCG (P < 0.01) and OHT (P < 0.05) groups. The amplitude and latency of the PEVP P100 component were analyzed. P100 latency was significantly delayed (P < 0.05) in SCG patients only. These findings suggest that the amplitude of the N95 component is the most sensitive electrophysiological parameter for early glaucoma detection.
目前有助于青光眼诊断的电生理技术包括图形视网膜电图（PERG）和图形视觉诱发电位（PEVP）记录。然而，在过去十年中，PERG已被公认为视网膜神经节细胞功能的良好指标。使用PERG（金箔电极）和PEVP记录对89名受试者的171只眼睛进行了研究。将分别包括32名高眼压症（OHT）患者和27名单纯慢性青光眼（SCG）患者的两组与由30名年龄匹配的健康受试者组成的对照组进行比较。关于PERG记录，测量了P50和N95成分的振幅，但仅在SCG组（P < 0.01）和OHT组（P < 0.05）中，N95振幅显示出统计学上的显著差异。分析了PEVP P100成分的振幅和潜伏期。仅在SCG患者中，P100潜伏期显著延迟（P < 0.05）。这些发现表明，N95成分的振幅是早期青光眼检测最敏感的电生理参数。
