Stavem K
Medisinsk avdeling Sentralsykehuset i Akershus, Nordbyhagen.
Tidsskr Nor Laegeforen. 1997 May 30;117(14):2038-9.
Paracetamol is among the most common substances consumed in self-poisoning attempts. The recommended treatment is intravenous N-acetylcysteine. Adverse reactions to this treatment are relatively common, but are rarely serious. The article reports and discusses a patient who had an anaphylactoid reaction to N-acetylcysteine after an overdose of paracetamol. This reaction was most probably an acute toxic effect of N-acetylcysteine, and not a result of an immunologic hypersensitivity reaction. Reducing the infusion rate of the initial loading dose might reduce the risk of adverse reactions. Recent guidelines recommend giving the loading dose over 60 minutes, instead of 15 minutes.
对乙酰氨基酚是自杀性中毒企图中最常摄入的物质之一。推荐的治疗方法是静脉注射N-乙酰半胱氨酸。这种治疗的不良反应相对常见，但很少严重。本文报告并讨论了一名对乙酰氨基酚过量后对N-乙酰半胱氨酸发生类过敏反应的患者。这种反应很可能是N-乙酰半胱氨酸的急性毒性作用，而非免疫超敏反应的结果。降低初始负荷剂量的输注速度可能会降低不良反应的风险。最近的指南建议将负荷剂量在60分钟内给予，而不是15分钟。
