Adda D H, Beraud E, Depieds R
Eur J Immunol. 1977 Sep;7(9):620-3. doi: 10.1002/eji.1830070908.
In this work we demonstrate a suppressive activity on the induction of experimental allergic encephalomyelitis (EAE) in Lewis rats, transferable to syngeneic animals, challenged with encephalitogenic mixture (myelin basic protein, complete Freud's adjuvant plus Bordetella pertussis organisms) 24 h later. This activity is probably effected by T cells and not by (an) inhibitory serum factor(s). The induction of this specific protection could be due to the penetration of the myelin basic protein antigen into the thymus where we first found suppressive cells. From the thymus, suppressor cells could then emigrate to spleen (on day 15) and to nondraining lymph nodes (on day 17). In the course of normal EAE in Lewis rats and especially at the time of self cure, this suppression is not demonstrated, but possible.
在本研究中，我们证明了对Lewis大鼠实验性变应性脑脊髓炎（EAE）诱导具有抑制活性，这种活性可转移至同基因动物，24小时后用致脑炎混合物（髓磷脂碱性蛋白、完全弗氏佐剂加百日咳杆菌）攻击。这种活性可能由T细胞介导，而非（一种）抑制性血清因子。这种特异性保护的诱导可能是由于髓磷脂碱性蛋白抗原渗入胸腺，我们首先在胸腺中发现了抑制性细胞。然后，抑制性细胞可从胸腺迁移至脾脏（第15天）和非引流淋巴结（第17天）。在Lewis大鼠正常EAE病程中，尤其是在自愈时，这种抑制作用未得到证实，但有可能存在。
