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Cooperative effects of hemicholinium-3 on high-affinity choline uptake by rat diaphragm.

作者信息

Veldsema-Currie R D

出版信息

Eur J Pharmacol. 1977 Oct 1;45(3):287-90. doi: 10.1016/0014-2999(77)90011-5.

DOI:10.1016/0014-2999(77)90011-5
PMID:923638
Abstract

Choline uptake in the end-plate rich area of rat diaphragm is saturable between 0.7 and 16 micron. This choline uptake obeys hyperbolic kinetics and indicates the presence of high-affinity carrier with Km values of 11.8 and 13.2 micron and Vmax values of 37 and 31 nmol choline/h/g tissue respectively. In the presence of hemicholinium-3 the carrier shows sigmoidal kinetics, and hemicholinium-3 is apparently a cooperative effector of choline uptake. The carrier is more calcium than sodium dependent.

摘要

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