Potentiating effect of (+)-sotalol and deoxysotalol on prostaglandin-evoked contractions of the isolated rat uterus.

The effect of (+)-sotalol and deoxysotalol on prostaglandin (PGF2a and 15-methyl PGF2alpha)-evoked contractions was studied using the isolated rat uterus. After control responses to prostaglandins had been obtained the uterus was exposed to the nutrient fluid containing 10 microgram/ml of (+)-sotalol, deoxysotalol or (--) sotalol. 30 min later the responses to prostaglandins were again recorded. Both (+)-sotalol and deoxysotalol potentiated PGF2alpha as well as 15-methyl PGF2alpha-induced contractions. (--)-Sotalol did not potentiate the PGF2alpha-evoked contractions of the isolated rat uterus. The possible clinical significance of the results is discussed.