舞蹈样手足徐动症作为加巴喷丁治疗对严重神经功能受损患者的副作用。
Choreoathetosis as a side effect of gabapentin therapy in severely neurologically impaired patients.
作者信息
Chudnow R S, Dewey R B, Lawson C R
机构信息
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, USA.
出版信息
Arch Neurol. 1997 Jul;54(7):910-2.
OBJECTIVE
To evaluate the relationship of gabapentin therapy with choreoathetotic movements in mentally retarded patients treated with intractable epilepsy.
DESIGN
Case reports of 2 institutionalized patients who developed choreoathetosis temporally related to adjunctive therapy with gabapentin at dosages of 1200 to 1800 mg/d.
RESULTS
Both patients experienced resolution of abnormal movements on discontinuation of the therapy. One patient developed recurrent choreiform movements after drug rechallenge.
CONCLUSION
We suggest that, in patients with mental retardation and epilepsy, involuntary movements may either occur as reversible side effects of gabapentin therapy or result from a previously undescribed adverse drug interaction with other antiepileptic agents.
目的
评估加巴喷丁治疗与患有难治性癫痫的智障患者舞蹈徐动症之间的关系。
设计
对2例机构收容患者的病例报告，这2例患者出现了与加巴喷丁辅助治疗（剂量为1200至1800毫克/天）时间相关的舞蹈徐动症。
结果
两名患者在停止治疗后异常运动均消失。一名患者在再次用药后出现复发性舞蹈样动作。
结论
我们认为，对于智障和癫痫患者，不自主运动可能是加巴喷丁治疗的可逆性副作用，或者是与其他抗癫痫药物发生了之前未描述的药物不良反应所致。
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