Wessel K, Zeffiro T, Toro C, Hallett M
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
J Neuroimaging. 1997 Jul;7(3):145-51. doi: 10.1111/jon199773145.
To evaluate the hypothesis that self-paced movements are mediated primarily by the supplementary motor area, whereas externally triggered movements are mainly affected by the lateral premotor cortex, different movements in 6 healthy volunteers were studied while changes in regional cerebral blood flow (rCBF) were measured using positron emission tomography (PET) and 15O-labeled water. Subjects made a series of finger opposition movements initiated in a self-paced manner every 4 to 6 seconds, and separately, made continuous finger opposition movements at a frequency of 2 Hz paced by a metronome. The primary motor cortex, lateral area 6, cerebellum on both sides, and caudal cingulate motor area, and the putamen and thalamus on the contralateral side were more active during the metronome-paced movements. The increases in rCBF in these areas are likely the result of the larger number of movements per minute made with the externally triggered task. The anterior supplementary motor area and rostral cingulate motor area in the midline, prefrontal cortices bilaterally, and lobus parietalis inferior on the ipsilateral side were more active during the self-paced movements. Increases in rCBF in those areas, which include medial premotor structures, may be related to the increased time devoted to planning the movement in this condition.
自主节奏运动主要由辅助运动区介导，而外部触发运动主要受外侧运动前皮层影响，我们使用正电子发射断层扫描（PET）和15O标记水测量局部脑血流量（rCBF）变化，同时研究了6名健康志愿者的不同运动。受试者每4至6秒以自主节奏进行一系列手指对指运动，另外，以节拍器设定的2Hz频率进行连续手指对指运动。在节拍器设定节奏的运动过程中，初级运动皮层、外侧6区、双侧小脑、尾侧扣带回运动区以及对侧的壳核和丘脑更为活跃。这些区域rCBF的增加可能是由于外部触发任务每分钟进行的运动次数更多。在自主节奏运动过程中，中线的前辅助运动区和喙侧扣带回运动区、双侧前额叶皮层以及同侧的顶下叶更为活跃。这些区域（包括内侧运动前结构）rCBF的增加可能与这种情况下用于计划运动的时间增加有关。
