Martin L N, Murphey-Corb M, Mack P, Baskin G B, Pantaleo G, Vaccarezza M, Fox C H, Fauci A S
Tulane Regional Primate Research Center, Tulane University, Covington, Louisiana 70433, USA.
J Infect Dis. 1997 Aug;176(2):374-83. doi: 10.1086/514054.
Virologic and immunologic effects of immunomodulation during primary simian immunodeficiency virus (SIV) infection were examined in monkeys treated with cyclosporin or vehicle for 32 days beginning 5 days before SIV inoculation. Duration of antigenemia decreased in 5 of 7 treated monkeys, 2 having delayed onset and peak of antigenemia. Although proviral DNA levels in blood and lymph nodes and infected cell numbers in lymph nodes were transiently decreased, levels were similar to those in controls by day 14. The CD4:CD8 ratio and percentage of CD4+ CD29+ cells decreased in controls 14 days after inoculation, but this decrease was delayed in treated monkeys. Two treated monkeys demonstrated rapid disease, with progressive antigenemia preceding early deaths 90-96 days after inoculation. Nevertheless, immunomodulation influenced the kinetics of primary SIV infection in some monkeys, supporting the rationale of careful exploration of the strategy of interference with the heightened state of cellular activation together with direct antiretroviral therapy in human immunodeficiency virus infection.
在接种猴免疫缺陷病毒（SIV）前5天开始，用环孢素或赋形剂对猴子进行32天治疗，研究了原发性SIV感染期间免疫调节的病毒学和免疫学效应。7只接受治疗的猴子中有5只的抗原血症持续时间缩短，2只抗原血症的发作和峰值出现延迟。尽管血液和淋巴结中的前病毒DNA水平以及淋巴结中的感染细胞数量暂时下降，但到第14天时，这些水平与对照组相似。接种后14天，对照组的CD4:CD8比值和CD4+CD29+细胞百分比下降，但在接受治疗的猴子中，这种下降出现延迟。两只接受治疗的猴子病情发展迅速，接种后90 - 96天出现进行性抗原血症，随后过早死亡。然而，免疫调节影响了一些猴子原发性SIV感染的动力学，这支持了在人类免疫缺陷病毒感染中仔细探索干扰细胞活化增强状态策略并结合直接抗逆转录病毒治疗的理论基础。
