Kudrin V S, Mineeva-Vialykh M F, Foklin V I
Farmakol Toksikol. 1977 Sep-Oct;40(5):527-31.
The effect of chronic (8-week long) 5 percent-ethanol consumption on the activity of tyrosine hydroxylase on the rat brain hypothalamus, striatum and midbrain was studied. In rats with strong ethanol prefence the enzyme activity was found to increase by 65-86 percent in the hypothalamus and to diminish by 52-68 percent and 29-68 percent in the midbrain and striatum, respectively. In rats with weak ethanol preference the enzyme activity in the brain striatum and midbrain remained unchanged, while in the hypothalamus it decreased by 25-40 percent. Chronic ethanol consumption had no effect on the inhibition of the enzyme activity neither by dopamine (8.0 X10(-4)M), nor tyrosine (in an inhibitory concentration of 3.7X(10(-4)M).
研究了长期（8周）摄入5%乙醇对大鼠脑下丘脑、纹状体和中脑酪氨酸羟化酶活性的影响。在强烈偏好乙醇的大鼠中，发现该酶活性在下丘脑中增加65% - 86%，在中脑和纹状体中分别降低52% - 68%和29% - 68%。在乙醇偏好较弱的大鼠中，脑纹状体和中脑的酶活性保持不变，而下丘脑中的酶活性降低25% - 40%。长期摄入乙醇对多巴胺（8.0×10⁻⁴M）或酪氨酸（抑制浓度为3.7×10⁻⁴M）对该酶活性的抑制均无影响。
