Dion A S
CRC Crit Rev Clin Lab Sci. 1979 Dec;11(3):245-70. doi: 10.3109/10408367909105858.
Relevant data pertaining to present evidence for virus-like particles and virus-related macromolecules in human milk and breast tumors are presented. A critical review and discussion of reported observations concerning virus-related macromolecules will include RNA-directed DNA polymerase, viral antigens, and RNA related to murine mammary tumor virus and/or Mason-Pfizer monkey virus. From the standpoint of clinical applications, the finding of viral-related antigens in human breast tumors and evidence for specific host immune responses to one or more of these antigens may be especially pertinent. The latter data, therefore, will be discussed in depth as to possible employment of these parameters in diagnosis, prognosis and possible management of the human disease.
本文展示了与人类乳汁和乳腺肿瘤中病毒样颗粒及病毒相关大分子的现有证据相关的数据。对有关病毒相关大分子的报道观察结果进行批判性回顾和讨论，将包括RNA指导的DNA聚合酶、病毒抗原以及与鼠乳腺肿瘤病毒和/或梅森- Pfizer猴病毒相关的RNA。从临床应用的角度来看，在人类乳腺肿瘤中发现病毒相关抗原以及针对这些抗原中一种或多种的特异性宿主免疫反应的证据可能尤为相关。因此，将深入讨论后者的数据，探讨这些参数在人类疾病诊断、预后及可能的治疗中的应用可能性。
