Gill D G, Vincent S, Segal D S
Children's Hospital, Dublin, Ireland.
Acta Paediatr. 1997 Jul;86(7):683-9. doi: 10.1111/j.1651-2227.1997.tb08568.x.
Six-month-old infants were recruited at 21 centres in the UK and Ireland and randomly assigned to receive matching iron-fortified (12.3 mg/l iron) or non-fortified (1.4 mg/l iron) formula for 9 months. Infants already receiving cow's milk continued this feed. Haematological indices and iron status were evaluated at age 6 months, 9-10 months and 15 months. Four hundred and six infants entered and 302 completed the study. There were no differences between the groups for increases in weight, head circumference or length. Significant differences between the groups were observed at 15 months for haemoglobin, serum ferritin, serum iron and total iron binding capacity. Haemoglobin levels were < 110 g/l in 33% of infants fed cow's milk compared with 13% and 11% in those receiving non-iron-fortified and iron-fortified formula respectively. The corresponding figures for serum ferritin < 10 microg/l were 43%, 22% and 6%. Follow-on formula provides an acceptable vehicle for preventing iron deficiency in this vulnerable group.
在英国和爱尔兰的21个中心招募了6个月大的婴儿，并将他们随机分配，分别接受9个月的含铁强化配方奶粉（铁含量为12.3毫克/升）或非强化配方奶粉（铁含量为1.4毫克/升）。已经在喝牛奶的婴儿继续饮用牛奶。在6个月、9至10个月和15个月时评估血液学指标和铁状态。406名婴儿进入研究，302名婴儿完成了研究。两组在体重、头围或身长增加方面没有差异。在15个月时，两组在血红蛋白、血清铁蛋白、血清铁和总铁结合力方面存在显著差异。喝牛奶的婴儿中33%的血红蛋白水平低于110克/升，相比之下，接受非铁强化配方奶粉和铁强化配方奶粉的婴儿中这一比例分别为13%和11%。血清铁蛋白低于10微克/升的相应比例分别为43%、22%和6%。后续配方奶粉是预防这一弱势群体缺铁的可接受载体。
