坏死性小肠结肠炎早产儿的肠道激素浓度

Gut hormone concentrations in preterm infants with necrotizing enterocolitis.

作者信息

Gounaris A, Alexiou N, Costalos C, Daniilidou M, Frangou E, Konstandellou E

机构信息

Neonatal Unit, Regional General Hospital of Piraeus, Nikea, Greece.

出版信息

Acta Paediatr. 1997 Jul;86(7):762-3. doi: 10.1111/j.1651-2227.1997.tb08582.x.

DOI:10.1111/j.1651-2227.1997.tb08582.x

PMID:9240887

Abstract

Blood levels of gastrin, neurotensin and vasoactive peptide (VIP) were estimated in 14 premature infants with necrotizing enterocolitis (NEC) and in 12 controls. In comparison to the control group, infants with NEC had (a) significantly lower gastrin levels both before [9.3 (7.8) versus 33.7 (27.1)] and after [52.4 (48.1) versus 100.8 (50.9)] the development of NEC; (b) significantly lower neurotensin levels only after the development of NEC [37.8 (10.4) versus 54.5 (20.6)1; and (c) no significant difference in VIP values [25.4 (9.7) versus 18.9 (9.9) and 24.5 (15.7) versus 26.1 (19.1)]. It is concluded that NEC can adversely affect gastrin and neurotensin concentrations in the blood.

摘要

对14例患有坏死性小肠结肠炎（NEC）的早产儿和12例对照组婴儿的胃泌素、神经降压素和血管活性肠肽（VIP）的血液水平进行了评估。与对照组相比，患有NEC的婴儿（a）在NEC发生之前[9.3（7.8）对33.7（27.1）]和之后[52.4（48.1）对100.8（50.9）]胃泌素水平均显著降低；（b）仅在NEC发生之后神经降压素水平显著降低[37.8（10.4）对54.5（20.6）]；以及（c）VIP值无显著差异[25.4（9.7）对18.9（9.9）以及24.5（15.7）对26.1（19.1）]。结论是，NEC可对血液中的胃泌素和神经降压素浓度产生不利影响。