Reynolds R D, Kamath B L
Eur J Pharmacol. 1979 Oct 26;59(1-2):115-9. doi: 10.1016/0014-2999(79)90032-3.
Open-chest dogs anesthetized with pentobarbital were treated with saline or N-acetylprocainamide (20 mg/kg, i.v.) 10 min prior to simultaneous ligation of the left anterior descending and septal coronary arteries. Ventricular fibrillation occurred in 20 of 26 control dogs but in only 6 of 15 dogs treated with N-acetylprocainamide (P less than 0.05). Since N-acetylprocainamide significantly reduced spontaneous heart rate this may have contributed to its antifibrillatory effect.
用戊巴比妥麻醉的开胸犬，在同时结扎左前降支冠状动脉和间隔冠状动脉前10分钟，用生理盐水或N-乙酰普鲁卡因胺（20毫克/千克，静脉注射）进行治疗。26只对照犬中有20只发生心室颤动，但在15只接受N-乙酰普鲁卡因胺治疗的犬中只有6只发生心室颤动（P小于0.05）。由于N-乙酰普鲁卡因胺显著降低了自发心率，这可能有助于其抗纤颤作用。
