由一族信号受体和诱饵受体对肿瘤坏死因子相关凋亡诱导配体（TRAIL）诱导的细胞凋亡进行调控。

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.

作者信息

Sheridan J P, Marsters S A, Pitti R M, Gurney A, Skubatch M, Baldwin D, Ramakrishnan L, Gray C L, Baker K, Wood W I, Goddard A D, Godowski P, Ashkenazi A

机构信息

Department of Molecular Oncology, Genentech, South San Francisco, CA 94080-4918, USA.

出版信息

Science. 1997 Aug 8;277(5327):818-21. doi: 10.1126/science.277.5327.818.

DOI:10.1126/science.277.5327.818

PMID:9242611

Abstract

TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4. The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli.

摘要

肿瘤坏死因子相关凋亡诱导配体（TRAIL，也称为Apo2L）属于肿瘤坏死因子家族，可激活肿瘤细胞中的快速凋亡，并与死亡信号受体DR4结合。另外还鉴定出了两种TRAIL受体。命名为死亡受体5（DR5）的受体含有一个细胞质死亡结构域，其诱导凋亡的方式与DR4非常相似。命名为诱饵受体1（DcR1）的受体表现出糖磷脂锚定细胞表面蛋白的特性。DcR1作为一种诱饵受体，可抑制TRAIL信号传导。因此，存在一种细胞表面机制来调节细胞对促凋亡刺激的反应性。