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Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis.前配体组装结构域介导的TRAIL受体4（TR4）与TR2之间不依赖配体的相互作用调节TRAIL诱导的细胞凋亡。
Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18099-104. doi: 10.1073/pnas.0507329102. Epub 2005 Nov 30.
2
Involvement of TRAIL/TRAIL-receptors in human intestinal cell differentiation.TRAIL/TRAIL受体在人肠道细胞分化中的作用。
J Cell Physiol. 2006 Mar;206(3):647-54. doi: 10.1002/jcp.20512.
3
Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity.诱饵受体2（DcR2）是一种p53靶基因，可调节化疗敏感性。
Cancer Res. 2005 Oct 15;65(20):9169-75. doi: 10.1158/0008-5472.CAN-05-0939.
4
Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand.Apo2配体/肿瘤坏死因子相关凋亡诱导配体激活激酶途径的分子决定因素
J Biol Chem. 2005 Dec 9;280(49):40599-608. doi: 10.1074/jbc.M509560200. Epub 2005 Oct 15.
5
Characterization of monoclonal antibodies directed against trail or trail receptors.针对肿瘤坏死因子相关凋亡诱导配体（TRAIL）或TRAIL受体的单克隆抗体的特性分析
Cell Immunol. 2005 Jul-Aug;236(1-2):86-91. doi: 10.1016/j.cellimm.2005.08.012. Epub 2005 Sep 12.
6
Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to TRAIL resistance and ovarian cancer.肿瘤坏死因子相关凋亡诱导配体受体1（DR4）的表观遗传沉默对TRAIL耐药性及卵巢癌的作用
Mol Cancer Res. 2005 Jun;3(6):335-43. doi: 10.1158/1541-7786.MCR-04-0136.
7
TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL.肿瘤坏死因子相关凋亡诱导配体（TRAIL）诱饵受体介导急性髓系白血病细胞对TRAIL的抗性。
Haematologica. 2005 May;90(5):612-24.
8
Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells.表面TRAIL诱饵受体-4的表达与MCF7乳腺癌细胞中的TRAIL抗性相关。
BMC Cancer. 2005 May 25;5:54. doi: 10.1186/1471-2407-5-54.
9
Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1.慢性淋巴细胞白血病细胞通过肿瘤坏死因子相关凋亡诱导配体受体1（TRAIL-R1）表现出凋亡信号。
Cell Death Differ. 2005 Jul;12(7):773-82. doi: 10.1038/sj.cdd.4401649.
10
Homomeric and heteromeric interactions of the extracellular domains of death receptors and death decoy receptors.死亡受体和死亡诱饵受体细胞外结构域的同聚体和异聚体相互作用。
Biochem Biophys Res Commun. 2005 May 20;330(4):1205-12. doi: 10.1016/j.bbrc.2005.03.101.

诱饵受体1和2对TRAIL介导的DR5-DISC形成的差异性抑制作用。

Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.

作者信息

Mérino Delphine, Lalaoui Najoua, Morizot Alexandre, Schneider Pascal, Solary Eric, Micheau Olivier

机构信息

INSERM, U517, Univ. Bourgogne, Dijon F-21000, France.

出版信息

Mol Cell Biol. 2006 Oct;26(19):7046-55. doi: 10.1128/MCB.00520-06.

DOI:10.1128/MCB.00520-06
PMID:16980609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1592888/
Abstract

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family that induces cancer cell death by apoptosis with some selectivity. TRAIL-induced apoptosis is mediated by the transmembrane receptors death receptor 4 (DR4) (also known as TRAIL-R1) and DR5 (TRAIL-R2). TRAIL can also bind decoy receptor 1 (DcR1) (TRAIL-R3) and DcR2 (TRAIL-R4) that fail to induce apoptosis since they lack and have a truncated cytoplasmic death domain, respectively. In addition, DcR1 and DcR2 inhibit DR4- and DR5-mediated, TRAIL-induced apoptosis and we demonstrate here that this occurs through distinct mechanisms. While DcR1 prevents the assembly of the death-inducing signaling complex (DISC) by titrating TRAIL within lipid rafts, DcR2 is corecruited with DR5 within the DISC, where it inhibits initiator caspase activation. In addition, DcR2 prevents DR4 recruitment within the DR5 DISC. The specificity of DcR1- and DcR2-mediated TRAIL inhibition reveals an additional level of complexity for the regulation of TRAIL signaling.

摘要

肿瘤坏死因子（TNF）相关凋亡诱导配体（TRAIL）是TNF家族的一员，它能以一定的选择性通过凋亡诱导癌细胞死亡。TRAIL诱导的凋亡由跨膜受体死亡受体4（DR4）（也称为TRAIL-R1）和DR5（TRAIL-R2）介导。TRAIL还可与诱饵受体1（DcR1）（TRAIL-R3）和DcR2（TRAIL-R4）结合，由于它们分别缺乏和具有截短的细胞质死亡结构域，因此无法诱导凋亡。此外，DcR1和DcR2抑制DR4和DR5介导的TRAIL诱导的凋亡，我们在此证明这是通过不同机制发生的。虽然DcR1通过在脂筏内滴定TRAIL来阻止死亡诱导信号复合物（DISC）的组装，但DcR2与DR5在DISC内共募集，在那里它抑制起始半胱天冬酶的激活。此外，DcR2阻止DR4在DR5 DISC内的募集。DcR1和DcR2介导的TRAIL抑制的特异性揭示了TRAIL信号调节的另一个复杂层面。