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加利利链霉菌（蒽环类抗生素加利红菌素的产生菌）的菌株改良。

Strain improvement in Streptomyces galilaeus, a producer of anthracycline antibiotics galirubins.

作者信息

Královocová E, Blumauerová M, Vanĕk Z

出版信息

Folia Microbiol (Praha). 1977;22(5):321-8. doi: 10.1007/BF02877666.

DOI:10.1007/BF02877666
PMID:924274
Abstract

The production of epsilon-pyrromycinone glycosides in Streptomyces galilaeus increased 12-fold, with respect to the wild strain, as a result of a sequential procedure including both natural selection and treatment with mutagens (nitrous acid, UV light and gamma-irradiation). Nitrous acid exhibited the highest mutagenic effect, both in increasing the productivity and in inducing blocked mutants. A mutant strain blocked in the biosynthesis of glycosides and accumulating free epsilon-pyrromycinone as the principal metabolite was obtained.

摘要

由于采用了包括自然选择和诱变剂（亚硝酸、紫外线和γ射线照射）处理在内的一系列步骤，加利利链霉菌中ε-吡咯霉素酮糖苷的产量相对于野生菌株提高了12倍。亚硝酸在提高产量和诱导受阻突变体方面均表现出最高的诱变效果。获得了一株在糖苷生物合成中受阻并积累游离ε-吡咯霉素酮作为主要代谢产物的突变菌株。

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Folia Microbiol (Praha). 1977;22(5):321-8. doi: 10.1007/BF02877666.
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本文引用的文献

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How many genes are required for the synthesis of chlortetracycline?合成金霉素需要多少个基因？
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Folia Microbiol (Praha). 1978;23(4):249-54. doi: 10.1007/BF02876677.
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Effect of aeration efficiency and carbon source on the production of anthracyclines in Streptomyces galilaeus.通气效率和碳源对加利利链霉菌蒽环类抗生素产量的影响。
Folia Microbiol (Praha). 1979;24(4):301-7. doi: 10.1007/BF02926648.
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Growth and production of anthracyclines in wild-type and mutant strains of Streptomyces galilaeus.
Folia Microbiol (Praha). 1979;24(4):296-300. doi: 10.1007/BF02926647.
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Intra- and interspecific cosynthetic activity of mutants of Streptomyces coeruleorubidus and Streptomyces galilaeus impaired in the biosynthesis of anthracyclines.在蒽环类生物合成中受损的天蓝链霉菌和加利利链霉菌突变体的种内和种间共合成活性。
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Use of mutagens in the improvement of production strains of microorganisms.诱变剂在微生物生产菌株改良中的应用。
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[Selection of a culture of Actinomyces coeruleorubidus, the producer of the antitumor antibiotic rubomycin].[抗肿瘤抗生素鲁保霉素产生菌天蓝链霉菌培养物的选择]
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How do antibiotic-producing microorganisms avoid suicide?产生抗生素的微生物是如何避免自我毁灭的？
Ann N Y Acad Sci. 1974 May 10;235(0):601-12. doi: 10.1111/j.1749-6632.1974.tb43294.x.
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The study of variability and strain selection in Streptomyces atroolivaceus. I. UV light and nitrous acid as effective agents in the improvement of mithramycin production.
Folia Microbiol (Praha). 1974;19(2):133-8. doi: 10.1007/BF02872846.
9
[Spontaneous and induced variability in Actinomyces rubiginosohelvolus, a new producer of the antibiotic rubomycin].[产抗生素鲁保霉素的新菌株红褐链霉菌的自发及诱导变异性]
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