持续血浆树脂灌注用于甲氨蝶呤解毒

Continuous plasma resin perfusion for detoxification of methotrexate.

作者信息

Greil J, Wyss P A, Ludwig K, Bonakdar S, Scharf J, Beck J D, Ruder H

机构信息

Klinik mit Poliklinik für Kinder und Jugendliche, University of Erlangen-Nürnberg, Germany.

出版信息

Eur J Pediatr. 1997 Jul;156(7):533-6. doi: 10.1007/s004310050656.

DOI:10.1007/s004310050656

PMID:9243235

Abstract

UNLABELLED

Acute renal failure is a rare but very severe side-effect of methotrexate (MTX) treatment requiring extracorporeal detoxification. A new detoxification regime, consisting of a haemodiafiltration (HDF) and continuous plasma resin perfusion (PRP) over anion exchange resin column with high affinity for MTX, was used for treatment of MTX-induced acute renal failure in a 2-year-old boy with medulloblastoma. More than 99% of MTX was removed from plasma by perfusion over the resin column resulting in a marked decrease of MTX plasma half-life. No haematological complications occurred.

CONCLUSION

The use of PRP alone or in combination with HDF is a new and effective treatment strategy for extracorporeal detoxification of MTX.

摘要

未标注

急性肾衰竭是甲氨蝶呤（MTX）治疗罕见但非常严重的副作用，需要进行体外解毒。一种新的解毒方案，包括血液透析滤过（HDF）和在对MTX具有高亲和力的阴离子交换树脂柱上进行连续血浆树脂灌注（PRP），用于治疗一名患有髓母细胞瘤的2岁男孩的MTX诱导的急性肾衰竭。通过在树脂柱上灌注，超过99%的MTX从血浆中被清除，导致MTX血浆半衰期显著缩短。未发生血液学并发症。