Frascella D W, Kampa I S, Francis B H
Horm Metab Res. 1977 Sep;9(5):374-8. doi: 10.1055/s-0028-1093531.
Blood lipids and glucose were studied in streptozotocin diabetic rats during hyperthermia. Blood glucose, free fatty acids (F.F.A.) and glycerol of diabetic rats with a rectal temperature of 42 degrees C (hyperthermic) were elevated significantly above those values found in normothermic (TR = 38 degrees C) diabetic or normothermic non-diabetic rats as well as hyperthermic non-diabetic rats. Streptozotocin diabetes caused an elevation in blood triglycerides of normothermic rats, but this hypertriglyceridemia was depressed in diabetic rats during hyperthermia. As in the case of diabetic animals, hyperthermia also caused a depression in the blood triglycerides of non-diabetic rats. However, unlike in the diabetic animals, the blood F.F.A. of non-diabetic rats were depressed during hyperthermia. Although hyperthermia caused a significant increase in the blood glucose of the diabetic animals, no significant change in blood glucose was shown in the hyperthermic non-diabetic rats. Blood cholesterol did not change significantly in the non-diabetic or diabetic animals during hyperthermia. The blood changes of these "energy substrates" are discussed with respect to their possible role in the extreme sensitivity of diabetics to high environmental temperature and "heat stress".
对链脲佐菌素诱导的糖尿病大鼠在高温状态下的血脂和血糖进行了研究。直肠温度为42摄氏度（高温）的糖尿病大鼠的血糖、游离脂肪酸（F.F.A.）和甘油水平显著高于正常体温（直肠温度=38摄氏度）的糖尿病大鼠、正常体温的非糖尿病大鼠以及高温的非糖尿病大鼠。链脲佐菌素诱导的糖尿病使正常体温大鼠的血液甘油三酯水平升高，但在高温期间，糖尿病大鼠的这种高甘油三酯血症有所减轻。与糖尿病动物的情况一样，高温也会使非糖尿病大鼠的血液甘油三酯水平降低。然而，与糖尿病动物不同的是，非糖尿病大鼠在高温期间血液中的游离脂肪酸水平降低。虽然高温使糖尿病动物的血糖显著升高，但高温的非糖尿病大鼠的血糖没有显著变化。在高温期间，非糖尿病或糖尿病动物的血液胆固醇水平没有显著变化。讨论了这些“能量底物”的血液变化与糖尿病患者对高环境温度和“热应激”极度敏感可能存在的关系。
