一氧化氮在2-脱氧-D-葡萄糖诱导的大鼠食欲亢进中的作用。

Involvement of nitric oxide in 2-deoxy-D-glucose-induced hyperphagia in rats.

作者信息

Yamada J, Sugimoto Y, Yoshikawa T, Horisaka K

机构信息

Department of Pharmacology, Kobe Pharmaceutical University, Japan.

出版信息

Neuroreport. 1997 Jul 7;8(9-10):2097-100. doi: 10.1097/00001756-199707070-00002.

DOI:10.1097/00001756-199707070-00002

PMID:9243591

Abstract

The effects of a nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on 2-deoxy-D-glucose (2-DG)-induced hyperphagia were investigated in rats. L-NAME dose-dependently inhibited 2-DG-induced eating in non-food-deprived rats, although the inactive isomer D-NAME on 2-DG-induced hyperphagia were inhibited by co-administration of L-arginine. The neuronal NO synthase inhibitor 7-nitroindazole also inhibited 2-DG-induced hyperphagia. These results suggest that 2-DG-induced hyperphagia is linked with NO and that brain NO may participate in this hyperphagic model.

摘要

研究了一氧化氮（NO）合酶抑制剂NG-硝基-L-精氨酸甲酯（L-NAME）对大鼠2-脱氧-D-葡萄糖（2-DG）诱导的摄食亢进的影响。L-NAME剂量依赖性地抑制未禁食大鼠中2-DG诱导的进食，尽管无活性的异构体D-NAME对2-DG诱导的摄食亢进的抑制作用可通过共同给予L-精氨酸而被阻断。神经元型NO合酶抑制剂7-硝基吲唑也抑制2-DG诱导的摄食亢进。这些结果表明，2-DG诱导的摄食亢进与NO有关，并且脑内的NO可能参与了这种摄食亢进模型。