Yamamoto T, Nozaki-Taguchi N
Department of Anesthesiology, School of Medicine, Chiba University, Japan.
Neuroreport. 1997 Jul 7;8(9-10):2179-82. doi: 10.1097/00001756-199707070-00018.
Prostaglandins, which are known to play an important role in the nociceptive transmission in the spinal cord, are produced by cyclooxygenase (COX). Two forms of COX have been identified, COX-1 (constitutive form) and COX-2 (a form highly inducible in response to inflammatory stimuli). COX-2 mRNA was reported to be expressed in the brain in normal rats in the absence of inflammation. We investigated the role of spinal COX-2 in the maintenance of thermal hyperalgesia induced by paw carageenan injection in the rat using NS-398, a selective COX-2 inhibitor. Intrathecally administered NS-398 attenuated the level of thermal hyperalgesia in a dose-dependent manner. This suggested that spinal COX-2 plays an important role in the maintenance of thermal hyperalgesia induced by paw carageenan injection.
前列腺素由环氧化酶（COX）产生，已知其在脊髓伤害性感受传递中起重要作用。已鉴定出两种形式的COX，即COX - 1（组成型）和COX - 2（一种对炎症刺激高度诱导的形式）。据报道，在没有炎症的正常大鼠脑中可表达COX - 2 mRNA。我们使用选择性COX - 2抑制剂NS - 398研究了脊髓COX - 2在大鼠爪注射角叉菜胶诱导的热痛觉过敏维持中的作用。鞘内注射NS - 398以剂量依赖性方式减轻热痛觉过敏水平。这表明脊髓COX - 2在爪注射角叉菜胶诱导的热痛觉过敏维持中起重要作用。
