Günel E, Tavll L, CaGlayan F, GündoGan A H
Department of Pediatric Surgery, Selçuk University Faculty of Medicine, Konya, Turkey.
Pediatr Surg Int. 1997 Jul;12(5-6):364-6. doi: 10.1007/BF01076940.
An isolated bowel segment (IBS) is a viable loop of bowel that is completely free of its mesenteric attachments. In this study, omentoenteropexy (OEP) was performed in 5-cm-long IBS of rats in order to provide neovascularization. Thirty-two rats were divided into four groups. After OEP, mesenteric division of the IBSs was performed at successive 1 week intervals in each group (3-6 weeks). The bowel-wall structures were histologically examined 2 days after division of the mesentery. Ischemic changes were observed in the group in which the interval was shorter than 4 weeks. In the IBSs that were supplied by the pediculated omental flap for 4 or more weeks no ischemic changes were noted in the mucosa, muscle layers, or intramural ganglia. We conclude that an IBS that preserves normal bowel structures can safely be created in the rat when its mesentery is divided 4 weeks after OEP. Physiological studies of motility and absorption can be performed and longitudinal tubularization may enable such an IBS to be used in short-bowel syndrome.
孤立肠段（IBS）是一段完全没有肠系膜附着的有活力的肠袢。在本研究中，为了实现新生血管形成，对大鼠5厘米长的IBS进行了网膜肠固定术（OEP）。32只大鼠被分为四组。OEP术后，每组在连续1周的间隔时间（3 - 6周）对IBS进行肠系膜离断。在肠系膜离断2天后对肠壁结构进行组织学检查。在间隔时间短于4周的组中观察到了缺血性改变。在由带蒂网膜瓣供血4周或更长时间的IBS中，在黏膜、肌层或壁内神经节未发现缺血性改变。我们得出结论，当在OEP术后4周对大鼠的肠系膜进行离断时，可以安全地创建保留正常肠结构的IBS。可以进行运动和吸收的生理学研究，并且纵向管状化可能使这样的IBS能够用于短肠综合征。
