Prockop D J, Guzman N A
Hosp Pract. 1977 Dec;12(12):61-8. doi: 10.1080/21548331.1977.11707242.
Increasing knowledge concerning the molecular structure of collagen and the steps involved in its biosynthesis provides the basis for a new look at the collagen diseases. Some, like the Ehlers-Danlos syndrome, are now known to be the expression of primary molecular defects; others, such as scurvy and scleroderma, appear to be secondary to some process that disrupts normal controls over collagen synthesis or deposition.
对胶原蛋白分子结构及其生物合成步骤的了解不断增加，为重新审视胶原蛋白疾病提供了依据。现在已知一些疾病，如埃勒斯-丹洛斯综合征，是原发性分子缺陷的表现；而其他一些疾病，如坏血病和硬皮病，似乎是某些破坏胶原蛋白合成或沉积正常调控过程的继发结果。
