Vergassola R, Mazzoli S, Fantini A, Tofani N, Semplici F, Bandini F, Iorno M, Salvi A, Rossi D
Divisione di Cardiologia, Ospedale S.M. Annunziata, Firenze.
G Ital Cardiol. 1997 May;27(5):470-5.
Chlamydia pneumoniae (C.p.) has been correlated with acute myocardial infarction (AMI). High levels of anti-C.p. antibodies and circulating immune complexes containing C.p. lypopolyaaccharide (LPS) antigens have been demonstrated in AMI. LPS antigen and especially Chlamydial LPS is one of the best antigen and it is also a very good Interleukin inductor. Moreover, interleukin 6 (IL-6) has been observed in AMI patients. The aim of our study was to assess the possible relationships between anti-C.p. immune response and IL-6 production in AMI patients. We studied 17 consecutive patients with myocardial infarction (12 males and 5 females; mean age 62; range 46-72). Blood samples were obtained immediately after hospital admission. There were 17 control subjects (HCM) (mean age 62; range 45-72) who were matched for the main coronary risk factors (gender, age, diabetes, hypertension, hypercolesterolemia, smoking, family history of ischemic heart disease). In addition, we evaluated the AMI patients in a one-year follow-up study (FU).
High levels of C.p. IgG MIF were found in 82.3% of our AMI patients and in 29.4% of HCM subjects (p = 0.0000065). IgA-MIF were 70.5% in AMI patients and 29.4% in HCM (p = 0.0042). High levels of C.p. IgG and IgA anti-LPS were found, with a very high prevalence rate of 76.4% and 64.7% in AMI patients, and both rates were 47.0% (p = 0.158; p = 0.489) in HCM. Very high levels of IL-6 were found (m = 54.38 pg/ml) in 100% of the AMI patients (normal values in our population: 0-10.86 pg/ml) and only detectable levels in 5.8% of HCM. A good linear correlation was demonstrated between IL-6 and IgA levels in the first sample (r = 0.655). The high levels of anti-C.p. IgG, IgA and IL-6, with a good correlation between IL-6 and IgA levels, may confirm the presence of an active infection and probably of a reinfection.
肺炎衣原体（C.p.）与急性心肌梗死（AMI）相关。在AMI患者中已证实存在高水平的抗C.p.抗体以及含有C.p.脂多糖（LPS）抗原的循环免疫复合物。LPS抗原，尤其是衣原体LPS是最佳抗原之一，也是一种非常好的白细胞介素诱导剂。此外，在AMI患者中观察到了白细胞介素6（IL-6）。我们研究的目的是评估AMI患者中抗C.p.免疫反应与IL-6产生之间的可能关系。我们研究了17例连续的心肌梗死患者（12例男性和5例女性；平均年龄62岁；范围46 - 72岁）。入院后立即采集血样。有17名对照受试者（肥厚型心肌病患者，HCM）（平均年龄62岁；范围45 - 72岁），他们在主要冠状动脉危险因素（性别、年龄、糖尿病、高血压、高胆固醇血症、吸烟、缺血性心脏病家族史）方面相匹配。此外，我们在一项为期一年的随访研究（FU）中对AMI患者进行了评估。
在我们82.3%的AMI患者和29.4%的HCM受试者中发现了高水平的C.p. IgG MIF（p = 0.0000065）。AMI患者中IgA - MIF为70.5%，HCM中为29.4%（p = 0.0042）。发现AMI患者中C.p. IgG和IgA抗LPS水平较高，患病率分别高达76.4%和64.7%，而在HCM中这两个比例均为47.0%（p = 0.158；p = 0.489）。在100%的AMI患者中发现IL - 6水平非常高（m = 54.38 pg/ml）（我们人群中的正常范围：0 - 10.86 pg/ml），而在HCM中只有5.8%可检测到。在第一个样本中，IL - 6与IgA水平之间显示出良好的线性相关性（r = 0.655）。高水平的抗C.p. IgG、IgA和IL - 6，以及IL - 6与IgA水平之间的良好相关性，可能证实存在活动性感染，可能还有再感染。
