Chivilev I V, Zolotukhina T V, Spitsyn V A, Nurbaev S D, Gribkova L G
Genetika. 1997 Mar;33(3):399-404.
This paper is the first in a series devoted to the investigation of the possible effect of maternal genotype on the levels of fetal alpha-fetoprotein (AFP) and human chorionic gonadotrophin (HCG) entering maternal blood. We studied the possible association between the maternal haptoglobin system and levels of maternal AFP and HCG, which are markers of fetal pathology. Haptoglobin types were determined in groups of pregnant women with different levels of serum markers. Distribution of haptoglobin types differed from the theoretically expected in one out of five groups tested. In the group with low AFP level, a significant decrease in frequency of the Hp*2 allele was found. A statistically significant decrease of the mean haptoglobin concentration in the group with low levels of AFP and elevated levels of HCG was observed. A reduction in serum haptoglobin concentration was shown to be accompanied by a decrease of serum iron concentration. The possible mechanism underlying the influence of maternal genotype on the levels of AFP and HCG in maternal blood are discussed.
本文是系列论文中的第一篇，致力于研究母体基因型对进入母体血液的胎儿甲胎蛋白（AFP）和人绒毛膜促性腺激素（HCG）水平的可能影响。我们研究了母体触珠蛋白系统与作为胎儿病理学标志物的母体AFP和HCG水平之间的可能关联。在具有不同血清标志物水平的孕妇组中确定触珠蛋白类型。在所测试的五组中，有一组触珠蛋白类型的分布与理论预期不同。在AFP水平低的组中，发现Hp*2等位基因频率显著降低。在AFP水平低且HCG水平升高的组中，观察到平均触珠蛋白浓度有统计学意义的降低。血清触珠蛋白浓度的降低伴随着血清铁浓度的降低。本文讨论了母体基因型影响母体血液中AFP和HCG水平的可能机制。
