Bading H, Hardingham G E, Johnson C M, Chawla S
MRC Laboratory of Molecular Biology, Cambridge, England.
Biochem Biophys Res Commun. 1997 Jul 30;236(3):541-3. doi: 10.1006/bbrc.1997.7037.
Calcium entry into neuronal cells through N-methyl-D-aspartate (NMDA)-type glutamate receptors or L-type voltage-gated calcium channels is a key event in the control of gene expression following electrical activation. Calcium acts both in the cytoplasm and the nucleus to activate signalling pathways that stimulate gene expression through different DNA regulatory elements. Differential control of transcription by spatially distinct calcium signals provides a mechanism by which a single second messenger can generate diverse transcriptional responses. This may allow for stimulation-specific modulation of gene expression critical for adaptive changes in the nervous system.
钙离子通过N-甲基-D-天冬氨酸（NMDA）型谷氨酸受体或L型电压门控钙通道进入神经元细胞，是电激活后基因表达调控中的关键事件。钙离子在细胞质和细胞核中均发挥作用，激活信号通路，通过不同的DNA调控元件刺激基因表达。空间上不同的钙信号对转录的差异控制提供了一种机制，通过该机制单个第二信使可产生多样的转录反应。这可能允许对神经系统适应性变化至关重要的基因表达进行刺激特异性调节。
