Preisler H D, Raza A, Bonomi P, Taylor S, LaFolette S, Leslie W, Lincoln S
Rush Cancer Institute, Chicago, Illinois 60612, USA.
Cancer Invest. 1997;15(4):358-68. doi: 10.3109/07357909709039740.
Attempts to improve the effectiveness of therapy for neoplastic diseases have largely focused on increasing the cytotoxic efficacy of therapy. While this approach is logical, there is another approach, based on the concept of regrowth resistance, which offers an alternate means of improving treatment outcome. The term "regrowth resistance" refers to the reduction in treatment efficacy resulting from the regrowth of neoplastic cells between courses of therapy or even between doses of radiation therapy. Regrowth resistance is likely to play a significant role in determining the outcome of treatment in rapidly proliferating neoplasms. A reduction in the rate of tumor regrowth would increase the net effectiveness of cytotoxic therapy and would also inhibit the development of resistance to cytotoxic therapies.
提高肿瘤疾病治疗效果的尝试主要集中在增强治疗的细胞毒性效力上。虽然这种方法合乎逻辑，但还有另一种基于再生抗性概念的方法，它提供了一种改善治疗结果的替代手段。“再生抗性”一词是指在疗程之间甚至放射治疗剂量之间肿瘤细胞再生导致治疗效果降低。再生抗性可能在决定快速增殖肿瘤的治疗结果中起重要作用。肿瘤再生速率的降低将提高细胞毒性治疗的净效力，也将抑制对细胞毒性疗法的抗性发展。
