Goldsmith D F
Public Health Institute, Berkeley, California 94704-1103, USA.
J Expo Anal Environ Epidemiol. 1997 Jul-Sep;7(3):291-301.
Although there has been debate in the medical community about silica's carcinogenicity since the 1930s, only in the past decade have there emerged scientific data supporting a causal association between industrial silica exposure and lung cancer. This paper examines the evidence for the association, with a particular focus on those studies appropriate for cancer risk assessment. The cancer risk extrapolations from epidemiology studies suggest that the levels of risks are approximately two factors less than that derived from animal studies. Additional research is needed to provide a stronger basis for the extrapolations so that policy makers can have more confidence in their estimates.
自20世纪30年代以来，医学界一直在讨论二氧化硅的致癌性，但直到过去十年才出现支持工业接触二氧化硅与肺癌之间存在因果关系的科学数据。本文研究了这种关联的证据，特别关注那些适用于癌症风险评估的研究。流行病学研究得出的癌症风险推断表明，其风险水平比动物研究得出的风险水平大约低两个数量级。需要进行更多研究，为这些推断提供更有力的依据，以便政策制定者对他们的估计更有信心。
